Thyroid status in preeclamptic patients and in normal pregnancy: A case control study

To compare thyroid profile in pre- eclamptic patients and normal normotensive pregnant women in between gestational age of 28-40 weeks of pregnancy. This case control study was done from Dec. 2015 to June 2017 in Geetanjali Medical College & Hospital, Udaipur. It was done on 50 patients of preeclampsia (case group) and 50 normal pregnant women (control group) in between gestational age of 28-40 weeks of pregnancy. Mean T 3 between case and control group was not statistically significant with p value = 0.844. Mean T 4 between case and control group was statistically significant with p value = 0.011. Mean TSH between case and control group was statistically significant with p value = 0.00068. Prevalence of hypothyroidism in patients of preeclampsia was 44% as compared to 16% in control group and p value was 0.00225, which was statistically significant. If the titers of TSH were above 4.04 μIU/ml in between gestational age of 28-40 weeks of pregnancy then there was 4 times higher risk of the development of preeclampsia. Present study suggested that pathogenesis of preeclampsia is related to primary hypo-functioning of the thyroid. Severity of preeclampsia correlated with modest decreases in thyroid hormones along with increased TSH level.