First trimester serum uric acid as an early predictor of gestational diabetes mellitus

First identified during pregnancy, GDM (Gestational diabetes mellitus) is referred by reduced glucose tolerance that results in varied degrees of hyper-glycemia. Usually, the diagnosis is made between twenty four to twenty eight weeks period of gestation. Compared to European women, South Asian, and especially Indian women have an 11 times elevated chance of developing GDM. GDM women are more prone to operative vaginal deliveries, cesarean sections, and complications such as shoulder dystocia during vaginal delivery due to the fetus having macrosomia or large for gestation. Screening and diagnostic methods for GDM depend largely on historical data, clinical examination, and laboratory tests like DIPSI and IADPSG. Early detection and prevention methods for GDM are limited. The purpose of this study was to evaluate the predictive value of serum uric acid levels in the first trimester for GDM in low-risk pregnant women. : Following obtaining permission, the level of serum uric acid had been measured from blood samples obtained from low-risk pregnant women. DIPSI testing was done twice, once between the weeks of gestation of 24 and 28 and then again between 28 and 32 weeks of gestation. Regression analysis employing receiver operating characteristic (ROC) curves and logistic regression was used to evaluate serum uric acid's capacity to predict GDM. The Youden index was utilized to establish the cut-off values. A statistically significant result was defined as having a p-value of <0.05. : 106 patients who met the study's inclusion criteria were included. The level of Serum uric acid in the 1 trimester had an AU-ROC of 0.8316 with a cut-off > 3.4 mg/dl, meaning 74.70% sensitivity and 82.61% specificity for GDM prediction. Serum uric acid and GDM showed a significant correlation (p < 0.001), according to logistic regression. Individuals whose level of serum uric acid is >3.4mg/dl had 14.02 times greater odds of suffering from GDM (95% CI: 4.28 - 45.92) than those with serum uric acid ≤ 3.4. : A one-year observational study conducted at the Dr. Prabhakar Kore Charitable Hospital and Research Centre, Belgaum, on behalf of KAHER revealed that the improvement of GDM can be predicted early with a 1 trimester serum uric acid cutoff of higher than 3.4 mg/dl.