Comparative analysis of safety, efficacy and fetomaternal outcome of cervical priming with mifepristone versus intracervical dinoprostone gel

The aim of this study was to evaluate the efficacy and safety of mifepristone forcervical ripening and induction of labor and compare the results with dinoprostone gelwhich is an established agent for labor induction. A total of 200 patients were enrolled in a prospective study and 100 eachwere assigned to either Mifepristone (M) Group and Dinoprostone (D) group. Outcome was evaluated using the improvement in Bishop score (BS), admission delivery interval, duration between induction and the onset of active phase of labor, mode of delivery and maternal and fatal outcomes. Though not statistically significant a single dose of 200mg Mifepristone resulted in better BS at 48hrs post application. The M group required lesser doses of Dinoprostone gel for labour induction and had lesser LSCS rates. The Apgar scores at1 and 5 mins were significantly better in M group. : The results of the study suggest that oral administration of 200mg mifepristone in term patients is more efficacious than Dinoprostone gel for cervical priming by achieving a better BS at 48 hrs. There is a significant reduction in application to delivery time and a significant reduction in LSCS rates.