[A Case of Esophageal Squamous Cell Carcinoma with Gastric Intramural Metastasis Showing Pathological Complete Response after Neoadjuvant Chemotherapy with Docetaxel, Cisplatin, and 5-Fluorouracil].

A 75-year-old man presenting with dysphagia was referred to our hospital and diagnosed with advanced esophageal squamous cell carcinoma(ESCC)accompanied by an intramural metastasis in the gastric wall. Following completion of 3 courses of neoadjuvant chemotherapy(NAC)with docetaxel/cisplatin/5-fluorouracil(DCF), the patient underwent minimally invasive esophagectomy with 3-field lymph node dissection. Histopathological examination showed no viable cancer cells in the esophageal and gastric wall, confirming a complete response. The patient was alive with no evidence of disease as of the 5-year postoperative follow-up. According to the results of a clinical trial conducted by the Japan Clinical Oncology Group (JCOG1109), DCF has become the standard NAC regimen for clinical Stage Ⅱ/Ⅲ ESCC. Although ESCC with a gastric intramural metastasis is notorious for its dismal prognosis, multidisciplinary treatment with intensive NAC and radical surgery may provide a cure for even for patients with highly advanced disease.