[A Case of Stage Ⅲ Esophagogastric Junction Adenocarcinoma with Lymph Node Metastasis Treated by Preoperative S-1 plus Oxaliplatin That Resulted in Pathological Complete Response].

We report a case of advanced esophagogastric junction adenocarcinoma with lymph node metastasis treated with preoperative S-1 plus oxaliplatin, resulting in a pathologic complete response was achieved. A 73-year-old woman was diagnosed with a large type 3 esophagogastric junction tumor with lymph node metastasis(GE, cT3N+M0, cStage Ⅲ), and was treated with 2 courses of neoadjuvant chemotherapy(NAC)with S-1/oxaliplatin combination therapy(SOX therapy). Gastrointestinal endoscopy showed remarkable reduction of the primary tumor, and abdominal computed tomography scan showed reduction of the enlarged lymph node. Robot-assisted esophagectomy with D2 dissection was performed. Histopathological examination revealed no residual tumor cells in the primary tumor or lymph nodes, and the response to chemotherapy was assessed as Grade 3(pCR).