The striatal matrix compartment is expanded in autism spectrum disorder
Matrix and striosome are embedded in distinct structural and functional networks, suggesting that compartment-selective injury or maldevelopment may mediate specific and distinct clinical features. Previously, assessing the striatal compartments in humans required post mortem tissue. Striatal parcellation provides a means to assess neuropsychiatric diseases for compartment-specific abnormalities. While this ASD cohort had increased matrix-like volume, other mechanisms that shift the matrix:striosome ratio may also increase the chance of developing the diverse social, sensory, and motor phenotypes of ASD.
Authors
- Jeff L. Waugh (ORCID: https://orcid.org/0000-0001-7526-1342)
- Joseph A. Maldjian (ORCID: https://orcid.org/0000-0002-6384-1072)
- Ayman Hassan (ORCID: https://orcid.org/0000-0002-7562-2002)
- Adrian T. Funk
Institutions
- The University of Texas at Dallas (US)
- Southwestern Medical Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s11689-025-09596-7
- Citations
- 8
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 10.88
Funders
- Brain and Behavior Research Foundation
- American Academy of Neurology
- National Institute of Neurological Disorders and Stroke