Metabolism‐inspired chemical reaction networks for chemically driven dissipative oligoesterification

Metabolism is a complex network of chemical reactions in which transient biomolecules are continuously produced and degraded. Mimicking this dynamic process in synthetic systems poses a considerable challenge, as it requires designs that enable the exchange of energy and matter among transient molecules. In this study, we explored a chemically driven oligoesterification process operating within a highly intricate reaction network and constructed a dynamic library of transient oligoesters. Our kinetic analysis uncovered an intriguing phenomenon: oligoesters undergo parasitic exchanges, consuming one another to sustain the system's dynamics before reaching thermodynamic equilibrium. This discovery opens new opportunities for designing synthetic systems that replicate the complexity and self-sustaining behavior of metabolic processes.

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Publication Details

Journal
Angewandte Chemie International Edition
Published
2025-02-15
DOI
https://doi.org/10.1002/anie.202425407
Primary Topic
Fuel Cells and Related Materials
Type
article
Field-Weighted Citation Impact
0.00

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article

Metabolism‐inspired chemical reaction networks for chemically driven dissipative oligoesterification

Jaeyoung Sung, Kyungtae Kang, Yeonsoo Lim, Hongyu An et al.
Angewandte Chemie International Edition
Fuel Cells and Related Materials
article

Metabolism‐inspired chemical reaction networks for chemically driven dissipative oligoesterification

Jaeyoung Sung, Kyungtae Kang, Yeonsoo Lim, Hongyu An, Gyunam Park, Sunbum Kwon, Joonhyun Bae, Ji‐Hyun Kim, Yan Lee, Jonghwa Han
article en

Abstract

Metabolism is a complex network of chemical reactions in which transient biomolecules are continuously produced and degraded. Mimicking this dynamic process in synthetic systems poses a considerable challenge, as it requires designs that enable the exchange of energy and matter among transient molecules. In this study, we explored a chemically driven oligoesterification process operating within a highly intricate reaction network and constructed a dynamic library of transient oligoesters. Our kinetic analysis uncovered an intriguing phenomenon: oligoesters undergo parasitic exchanges, consuming one another to sustain the system's dynamics before reaching thermodynamic equilibrium. This discovery opens new opportunities for designing synthetic systems that replicate the complexity and self-sustaining behavior of metabolic processes.

Angewandte Chemie International EditionVol. 64(14)
Seoul National University (KR), Kyung Hee University (KR), Creative Research (GB), Chung-Ang University (KR)
University of Miami, National Research Foundation, Chung-Ang University, National Research Foundation of Korea
Responsible consumption and production
Openalex Percentile: Top 98%
Fuel Cells and Related Materials
DOIOpen Access PDFOpenAlex
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