Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway
These results reveal that exosomal miR-205 plays a pivotal role in macrophage polarization within the OC microenvironment, highlighting its potential as a therapeutic target for OC treatment. This study not only enhances our understanding of the interactions between tumour and immune cells but also opens new avenues for targeted therapies against exosomal miR-205 in ovarian cancer.
Authors
- Xiaoying Wu (ORCID: https://orcid.org/0000-0002-2977-3280)
- Quan Chen (ORCID: https://orcid.org/0000-0002-6816-5413)
- Liuqing He (ORCID: https://orcid.org/0000-0002-2577-9722)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s13048-025-01616-3
- Citations
- 14
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 11.28
Funders
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hunan Province
- Xiangya Hospital, Central South University