Comorbidity of periodontal pathology and ulcer disease

Peptic ulcer disease is a chronic relapsing disease that occurs with alternating periods of exacerbation and remission, the leading manifestation of which is the formation of a defect (ulcer) in the wall of the stomach and duodenum. Periodontitis is the sixth most common disease in the world (among dental pathologies, the 2nd after caries) and the leading cause of tooth loss in adults. At the beginning of the 21st century, the concept of "periodontal medicine" was formed, within the framework of which a bidirectional relationship between periodontal pathology and systemic diseases of the body is considered. We searched the Pubmed and Scopus information databases for articles published before September 20, 2024, which considered the relationship between peptic ulcer disease and periodontal pathology. The results of clinical studies, their generalizations in systematic reviews and meta-analyses, indicate the presence of a bidirectional relationship between peptic ulcer disease and periodontal pathology. Possible mechanisms of this relationship require further study. Helicobacter pylori is certainly a key linking factor. The oral cavity can act as a reservoir, as well as in the transmission and colonization of Helicobacter pylori. Non-surgical periodontal treatment increases the effectiveness of standard eradication therapy, which is advisable to take into account in real clinical practice.