Ancient Medicinal Insect Steleophaga Plancyi (Boleny)-Derived Extracellular Vesicle-Like Particles Enhances Autophagic Activity to Promote Osteogenic Differentiation via Melatonin in Osteoporosis
Our results establish SP-EVLP as a promising therapeutic candidate for osteoporosis. The activation of melatonin-induced autophagy by SP-EVLP suggests a molecular mechanism for its osteoprotective effects, opening new possibilities for osteoporosis treatment development.
Authors
- Peicong Chen (ORCID: https://orcid.org/0000-0002-5828-8700)
- Yuanyuan Liu
- Peng Li (ORCID: https://orcid.org/0000-0003-1695-512X)
- Zhen Shi (ORCID: https://orcid.org/0009-0006-7270-1166)
- Shengquan Yu
- Jiaxu Lu
- Hao Lin (ORCID: https://orcid.org/0000-0001-6387-4037)
- Jiaxian Chen (ORCID: https://orcid.org/0000-0002-6592-5173)
- Y. J. Jiang (ORCID: https://orcid.org/0000-0002-0656-8647)
Institutions
- Guangdong Medical College (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijn.s505443
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61