A Novel <i>ACVR2A::RAF1</i> Fusion in Spindle Cell Sarcoma
The ACVR2A::RAF1 fusion represents a novel genomic profile in RAF1-rearranged spindle cell sarcoma, offering a rational basis for targeted therapy. This case highlights the importance of molecular diagnostics in identifying actionable targets and guiding treatment, potentially leading to significant clinical benefits.
Authors
- Huafei Chen
- Rong Rong (ORCID: https://orcid.org/0000-0003-2423-4082)
- Anfeng Jiang (ORCID: https://orcid.org/0009-0003-9357-7844)
- Huan Li (ORCID: https://orcid.org/0000-0003-2089-0613)
- Bin Li (ORCID: https://orcid.org/0000-0002-3769-7476)
- Ying Zhang (ORCID: https://orcid.org/0009-0000-4391-5516)
- Dongbing Li (ORCID: https://orcid.org/0000-0002-5227-9643)
- Lina Zhao (ORCID: https://orcid.org/0000-0002-0011-6471)
- Sheng Xiao (ORCID: https://orcid.org/0000-0001-6458-2490)
- Yangyang Li (ORCID: https://orcid.org/0009-0003-2578-856X)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Central South University (CN)
- Soochow University (CN)
- Xiangya Hospital Central South University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- Genes Chromosomes and Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/gcc.70033
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Central South University
- Natural Science Foundation of Hunan Province