Detections of rare enterovirus C105 linked to an emerging novel clade, Spain, 2019 to 2024
Enterovirus (EV)-C105 is a rare genotype not previously detected in Spain. Between 2019 and 2024, we detected EV-C105 in respiratory samples of five patients, through routine EV surveillance. Three cases had respiratory illness and two were hospitalised for neurological illness. Four of the five sequenced strains belonged to an emerging clade (C1), defined by four novel nonsynonymous mutations in key antigenic epitopes. We recommend reinforced clinical awareness and EV genomic surveillance, including respiratory samples, even when symptoms are neurological.
Authors
- Ana Navascués (ORCID: https://orcid.org/0000-0002-1372-9680)
- Juan Pedro M. Camacho (ORCID: https://orcid.org/0000-0002-2507-9814)
- María Teresa Pastor-Fajardo (ORCID: https://orcid.org/0000-0001-5991-0752)
- Carla Berengua (ORCID: https://orcid.org/0000-0001-9963-3809)
- María Dolores Fernández-García (ORCID: https://orcid.org/0000-0003-0336-6596)
- María Cabrerizo (ORCID: https://orcid.org/0000-0001-7054-5696)
- Francisco Díez‐Fuertes (ORCID: https://orcid.org/0000-0003-2413-9229)
- Montserrat Ruiz‐García (ORCID: https://orcid.org/0000-0002-3558-2763)
- Nerea García-Ibañez
- Estrella Ruiz de Pedro
- Pedro Antequera-Rodriguez
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Hospital General Universitario Morales Meseguer (ES)
- Centro Nacional de Microbiologia (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital General Universitario de Elche (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Eurosurveillance
- Published
- 2025-02-13
- DOI
- https://doi.org/10.2807/1560-7917.es.2025.30.6.2500073
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78