Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway
Irisin mitigates oxidative stress and inflammation by modulating the PERK-eIF2α-ATF4 pathway, highlighting its potential as a prospective approach for combating DOX-induced cardiotoxicity.
Authors
- Yongguo Liu (ORCID: https://orcid.org/0000-0002-4906-7025)
- Wenbo Fu
- Xiaolin Yu (ORCID: https://orcid.org/0000-0003-0379-5622)
- Xiangyu Dong (ORCID: https://orcid.org/0009-0003-5638-7558)
- Zilong Zhang (ORCID: https://orcid.org/0000-0002-7003-6565)
- Jie Li (ORCID: https://orcid.org/0000-0003-0837-5133)
- Zhao Wang (ORCID: https://orcid.org/0000-0002-3628-5699)
- Xin Shen (ORCID: https://orcid.org/0000-0002-3825-5872)
Institutions
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s492691
- Citations
- 7
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 9.72