Tumor Mutation Burden Survey of AACR GENIE Database Revealed NTRK (<scp><i>NTRK</i></scp>+) and RET (<scp><i>RET</i></scp>+) Fusions Positive Colorectal Carcinoma (CRC) as Distinct Subsets
NRTK+ and RET+ CRC possess significantly higher TMB than other RTK+ CRC or NTRK+/RET+ non-CRC solid tumors. TMB testing should be routinely done in MSI-H CRC, and TMB ≥ 35 mut/MB samples should be screened for NTRK and RET fusions as an enrichment strategy to provide additional treatment for NTRK+ and RET+ CRC patients.
Authors
- Alexandria TM Lee (ORCID: https://orcid.org/0000-0002-2618-8131)
- Misako Nagasaka (ORCID: https://orcid.org/0000-0001-5308-615X)
- Sai‐Hong Ignatius Ou (ORCID: https://orcid.org/0000-0002-1764-4975)
- Zhaohui Arter (ORCID: https://orcid.org/0000-0001-7394-7156)
Institutions
- University of California, Irvine (US)
- Community Cancer Center (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/cam4.70665
- Citations
- 2
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.09