Clinicopathological Study on Morphological Subtypes of Hepatocellular Carcinoma: A Single Tertiary Referral Center Experience
Although the most common morphologic subtype was steatohepatitic HCC, the majority of cases demonstrated multiple morphologic patterns. In case of HCC-NOS, heterogeneous GPs were often observed. Therefore, a histomorphological diagnosis based on a single tumor biopsy specimen may lead to incorrect classification of HCC. Sufficient tumor sampling of HCC resection specimens is required for the complete evaluation of all histomorphological features followed by correct subclassification in order to meet the clinical needs regarding prognostic relevance and patient follow-up.
Authors
- Véronique Winnepenninckx (ORCID: https://orcid.org/0000-0002-9625-2442)
- Axel zur Hausen (ORCID: https://orcid.org/0000-0002-4781-0372)
- Stefan A.W. Bouwense (ORCID: https://orcid.org/0000-0002-7600-9429)
- Mariëlle M.E. Coolsen (ORCID: https://orcid.org/0000-0002-1608-6668)
- Tom J.G. Gevers (ORCID: https://orcid.org/0000-0002-3070-8443)
- Dorit Rennspiess
- Steven W.M. Olde Damink (ORCID: https://orcid.org/0000-0002-5202-9345)
- Jan Beckervordersandforth (ORCID: https://orcid.org/0009-0002-8894-6230)
- Iryna Samarska (ORCID: https://orcid.org/0000-0003-4092-0672)
- Marc H.A. Bemelmans
- Maxime Dewulf (ORCID: https://orcid.org/0000-0002-1945-5481)
- M. Kramer (ORCID: https://orcid.org/0000-0001-8621-1607)
- Shijin Shuai (ORCID: https://orcid.org/0000-0002-0108-3368)
- Christine Saler
- Guido M.J.M. Roemen
- M. C. F. Stoehr‐Kleinegris
Institutions
- Maastricht University (NL)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/cnr2.70127
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00