Extraction of Marine Polyketides from Different Seaweeds and Analyzing its Antibacterial and Anti-Cancer Activity

Aim: Three different seaweeds were collected in the present study and aimed to investigate its antibacterial activity against human bacterial pathogens and anticancer activity against human breast cancer cell lines (MCF-7) respectively.Methods: Three seaweeds were collected and its bioactive compounds were extracted using soxhlet method to determine the minimal inhibitory concentration (MIC) and antibacterial activity against different pathogenic bacteria.Anti-cancer activity of the extracts in breast cancer cell lines (MCF-7) cells using MTT assay method was investigated.Findings: MIC of all three seaweed extracts was found to be 300g/ml with the inhibitory zones ranging from 8.6 0.75mm to 16.3 1.05mm against the respective bacteria Escherichia coli and Staphylococcus aureus.Antibacterial activity of three different seaweed extracts showed significant inhibitory zones ranging from 13.3 1.05mm to 16.9 0.57mm against the respective bacteria B1 -Escherichia coli, B2 -Staphylococcus aureus, B3 -Staphylococcus epidermidis, B4 -Klebsiella pneumoniae, B5 -Enterobacter sp.Anticancer activity test results revealed IC50 value of about 43.5g/ml for the brown seaweed extracts after testing in MCF-7 cell lines.Increase in concentration of samples increased the cell cytotoxicity and proliferation of cancer cells were inhibited in a dose dependent manner. Conclusion:Thus, the obtained results would contribute more and induce interest for the development of different medically significant seaweed farming and biotechnological use with growing interest.