Investigation of Placentas of Preeclamptic Patients with Very Premature Membrane Rupture

Purpose: In this study, placental histological differences between the control group and the PROM+preeclampsia group were evaluated. Materials and Methods: In our study, placentas were obtained from a total of 90 pregnant patients (regardless of age), including 45 control and 45 PROM+Preeclampsia pregnant patients, by obtaining informed consent form. Results: In the control group, placental structures appeared normal with regular chorionic villi, properly organized trophoblast layers, minimal syncytial nodes, and limited fibrin accumulation. Villous capillary endothelial cells were thin and elongated, while stromal cells were well-placed without signs of bleeding or inflammation. In the PROM+preeclampsia group, villous degeneration, trophoblastic apoptosis, vascular congestion, endothelial hyperplasia, and increased fibrin deposition were observed. The intervillous area showed extensive hemorrhage and immune cell infiltration, with numerous Hoffbauer cells in the villous stroma and marked decidual cell degeneration near the maternal plate. Conclusion: In our study, placental histopathological changes observed in the PROM+preeclampsia group show that this condition may seriously affect the placental structure. Keywords: placenta, PROM, histopathology, preeclampsia