Emergence of population heterogeneity in Klebsiella pneumoniae with a blaOXA-232-harboring plasmid: carbapenem resistance, virulence, and fitness
This study demonstrated that underlying heterogeneity can promote the emergence of stable, high-level antibiotic resistance, even with the introduction of a plasmid carrying a low-level antibiotic resistance gene, such as bla<sub>OXA-232.</sub> This highlights the critical need to closely monitor bacterial population dynamics.
Authors
- Kwan Soo Ko (ORCID: https://orcid.org/0000-0002-0978-1937)
- Sun Ju Kim (ORCID: https://orcid.org/0000-0002-2384-2425)
- Yun Young Cho
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s12929-024-01108-4
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Samsung