Heterologous Effects of Pertussis and Influenza Vaccines During Pregnancy on Maternal and Infant Innate Immune Responses: A Pilot Study
Our pilot study suggests that PBMC from women receiving combined Tdap and influenza vaccination during pregnancy may have reduced in vitro cytokine responses to nonpertussis stimuli. Larger cohorts of mother-infant pairs need to be studied to confirm these findings, study the potential mechanisms and control for potential confounders.
Authors
- Khaleda Islam (ORCID: https://orcid.org/0000-0002-8303-0947)
- Vanessa Sancho‐Shimizu (ORCID: https://orcid.org/0000-0002-3519-0727)
- Beth Holder (ORCID: https://orcid.org/0000-0003-2157-9819)
- Beate Kampmann (ORCID: https://orcid.org/0000-0002-6546-4709)
- Thomas F. Rice (ORCID: https://orcid.org/0000-0001-6975-5530)
- Dimitri A. Diavatopoulos (ORCID: https://orcid.org/0000-0001-7065-7807)
Institutions
- Radboud University Nijmegen (NL)
- Queen Mary University of London (GB)
- Radboud University Medical Center (NL)
- Imperial College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1097/inf.0000000000004676
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- NIHR Imperial Biomedical Research Centre