Soluble CD14 and IL-12p70 on early antiretroviral therapy predict HIV load setpoint after treatment interruption
An increased pVL setpoint was associated with higher sCD14 and lower IL-12p70 at ATI, and increased total HIV-DNA was associated with higher sCD163 at ATI. SCD14 and sCD163 are biomarkers of monocyte activation, whereas IL-12p70, produced by monocytes, is essential for inducing Th1 responses. This underscores the relation between immune activation and diminished immune control of HIV. Our findings indicate that sCD14 and IL-12p70 could serve as predictive biomarkers for favorable outcomes in cure interventions.
Authors
- Agnes M. Harskamp
- Anders C. Boyd (ORCID: https://orcid.org/0000-0001-9512-8928)
- Alexander Pasternak (ORCID: https://orcid.org/0000-0002-4097-4251)
- Irma Maurer (ORCID: https://orcid.org/0000-0003-2864-2139)
- Jan M. Prins (ORCID: https://orcid.org/0000-0002-5415-8933)
- Godelieve J. de Bree (ORCID: https://orcid.org/0000-0002-5852-5833)
- Neeltje A. Kootstra (ORCID: https://orcid.org/0000-0001-9429-7754)
- Suzanne Jurriaans
- Marlous L. Grijsen (ORCID: https://orcid.org/0000-0002-7335-7313)
- Pien M. van Paassen
Institutions
- University of Indonesia (ID)
- University of Oxford (GB)
- Netherlands Center for Occupational Diseases (NL)
- Stichting HIV Monitoring (NL)
- Amsterdam University Medical Centers (NL)
- Oxford University Clinical Research Unit Indonesia
- University of Amsterdam (NL)
Publication Details
- Journal
- AIDS
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1097/qad.0000000000004159
- Citations
- 2
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.07