A role for arginase in skin epithelial differentiation and antimicrobial peptide production
ARG1 activity plays a major role in keratinocyte differentiation and AMP production. ARG1 is downregulated in an AD model, and in cell systems its function can be rescued by the ARG1 downstream products putrescine and urea. Manipulation of the ARG1 pathway may have the potential to be used for the management of skin conditions such as AD.
Authors
- Denis Szondi (ORCID: https://orcid.org/0000-0002-1549-7713)
- Leah A. Vardy (ORCID: https://orcid.org/0000-0003-4186-684X)
- Joanne L. Pennock (ORCID: https://orcid.org/0000-0002-8304-2905)
- Rachel A Crompton (ORCID: https://orcid.org/0000-0001-5878-9292)
- Carine Bonnard (ORCID: https://orcid.org/0000-0003-1922-017X)
- Sheena Cruickshank (ORCID: https://orcid.org/0000-0002-3047-5475)
- Sze Han Lee (ORCID: https://orcid.org/0000-0003-2987-9939)
- Thiam Chye Lim (ORCID: https://orcid.org/0000-0001-6084-2902)
- Linus Oon (ORCID: https://orcid.org/0009-0005-6311-0359)
- Jason Wong (ORCID: https://orcid.org/0000-0003-2592-3226)
- Khek‐Chian Tham (ORCID: https://orcid.org/0000-0002-5702-2986)
- Nagavidya Subramaniam (ORCID: https://orcid.org/0000-0002-6169-710X)
- Helen Williams (ORCID: https://orcid.org/0000-0001-5723-501X)
Institutions
- Agency for Science, Technology and Research (SG)
- National Skin Centre (SG)
- National University of Singapore (SG)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Institute of Immunology (HR)
- National University Hospital (SG)
- A*STAR Graduate Academy (SG)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1093/bjd/ljaf057
- Citations
- 5
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 10.02
Funders
- Agency for Science, Technology and Research
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council