Prevalence of idiopathic normal pressure hydrocephalus in older adult population in Shanghai, China: A population‐based observational study
<sup>**</sup>Significant Prevalence<sup>**</sup>: The study identified a substantial prevalence of iNPH in older adults, with rates increasing significantly with age, particularly among those aged 90-99 years and centenarians. <sup>**</sup>Diagnostic Approach<sup>**</sup>: The research utilized novel diagnostic methodologies by integrating the DESH score or Radscale score with stringent clinical symptoms, providing a closer approximation to the true prevalence of iNPH. <sup>**</sup>Gender Disparity<sup>**</sup>: A marked gender difference was observed, with the prevalence of iNPH being significantly higher in males compared to females across all age groups. <sup>**</sup>Clinical Implications<sup>**</sup>: The findings underscore the importance of considering iNPH in the differential diagnosis of dementia, particularly among older male patients presenting with cognitive impairment and gait disturbances. <sup>**</sup>Public Health Impact<sup>**</sup>: The estimated number of s-probable iNPH patients in Shanghai highlights the need for increased awareness and better management strategies for this underdiagnosed condition in the aging population.
Authors
- Yan Xing (ORCID: https://orcid.org/0000-0001-5299-1967)
- Shihong Li (ORCID: https://orcid.org/0000-0002-2204-7593)
- Xuhao Fang (ORCID: https://orcid.org/0000-0002-3733-3568)
- Yao Deng (ORCID: https://orcid.org/0000-0002-9411-9250)
- Jin Hu (ORCID: https://orcid.org/0000-0002-0504-960X)
- Chunyan Liu (ORCID: https://orcid.org/0000-0002-5893-8507)
- Li Zhang (ORCID: https://orcid.org/0000-0002-8583-3452)
- Feng Tang (ORCID: https://orcid.org/0000-0003-3824-7108)
- Xinxin Xu (ORCID: https://orcid.org/0009-0000-3382-9438)
- Renling Mao (ORCID: https://orcid.org/0000-0001-7927-6197)
Institutions
- Fudan University (CN)
- Huadong Hospital (CN)
- Huashan Hospital (CN)
- Aviation General Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14525
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality