Design, synthesis, and biological evaluation of oxime ether derivatives containing 1,5‐dimethyl‐6‐thioxo‐1,3,5‐triazinane‐2,4‐dione as protoporphyrinogen <scp>IX</scp> oxidase inhibitors
Through bioisosterism and substructure splicing, we successfully developed compound 6r as lead compound exhibiting herbicidal activity, with no harm to rice and honeybees. Further development of herbicides based on this scaffold is warranted. © 2025 Society of Chemical Industry.
Authors
- Dingfeng Luo
- Changsheng Ma (ORCID: https://orcid.org/0000-0002-5387-5957)
- Hao Li (ORCID: https://orcid.org/0000-0002-0071-2863)
- Yingying Wang (ORCID: https://orcid.org/0000-0002-0603-6691)
- Sheng Yan
- Lianyang Bai (ORCID: https://orcid.org/0000-0003-1605-9173)
- Yuanhui Wan
- Zuren Li
- Zhendong Bai
Institutions
- Hunan University (CN)
- Hunan Academy of Agricultural Sciences (CN)
- Yueyang Changling Equipment Research Institute (China) (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1002/ps.8703
- Citations
- 3
- Primary Topic
- Pesticide and Herbicide Environmental Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.51
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- National Key Research and Development Program of China