Efficacy of Tirzepatide Dual <scp>GIP</scp> / <scp>GLP</scp> ‐1 Receptor Agonist in Patients With Idiopathic Intracranial Hypertension. A Real‐World Propensity Score‐Matched Study
Our results demonstrate that tirzepatide, when used as an adjunctive therapy, provides significant therapeutic benefits in IIH management, particularly in improving papilledema and visual outcomes. Our findings suggest that dual GIP/GLP-1 receptor activation may offer advantages over traditional single-receptor therapies, potentially through enhanced metabolic regulation and direct effects on ICP dynamics.
Authors
- Neil Haranhalli (ORCID: https://orcid.org/0000-0003-2721-8600)
- Deepak Khatri (ORCID: https://orcid.org/0000-0003-1902-9623)
- David Altschul (ORCID: https://orcid.org/0000-0002-5130-1378)
- Ahmed Saad Al Zomia (ORCID: https://orcid.org/0000-0002-7850-7229)
- Muhammed Amir Essibayi (ORCID: https://orcid.org/0000-0001-8325-2382)
- Adam Andrew Dmytriw (ORCID: https://orcid.org/0000-0003-0131-5699)
- Hammam A Alotaibi
- Oday Atallah (ORCID: https://orcid.org/0000-0002-3131-4104)
- Hana J Abukhadijah (ORCID: https://orcid.org/0009-0008-7993-7467)
- Mohammed A. Azab (ORCID: https://orcid.org/0000-0002-3519-9035)
- Amanda Baker (ORCID: https://orcid.org/0000-0002-0291-707X)
- Nathan Farkas
- Adam Elswedy
- Ahmed Y. Azzam (ORCID: https://orcid.org/0000-0002-4256-0159)
- Ahmed Alamoud
- Mahmoud M Morsy (ORCID: https://orcid.org/0009-0001-4356-5306)
- Osman Elamin
Institutions
- Uppsala University (SE)
- Brigham and Women's Hospital (US)
- St. Michael's Hospital (CA)
- Albert Einstein College of Medicine (US)
- Cleveland Clinic (US)
- Montefiore Medical Center (US)
- Riyadh Armed Forces Hospital (SA)
- Harvard University (US)
- University of Toronto (CA)
- Jordan Hospital (JO)
- Medizinische Hochschule Hannover (DE)
- Massachusetts General Hospital (US)
- Neurological Surgery (US)
- October 6 University (EG)
- Hamad Medical Corporation (QA)
- King Khalid University (SA)
Publication Details
- Journal
- Endocrinology Diabetes & Metabolism
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1002/edm2.70019
- Citations
- 12
- Primary Topic
- Cerebral Venous Sinus Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 16.67
Funders
- Qatar National Library
- National Center for Advancing Translational Sciences