Rheumatoid arthritis-associated rheumatoid factors post-COVID-19
Rheumatoid arthritis-associated RFs are primarily restricted to rheumatoid arthritis, but some individuals post-COVID-19 generate moderate levels of a few rheumatoid arthritis-associated RFs, especially of the IgA isotype and homocitrulline-reactive. These findings refine our understanding of RFs, provide novel insights into loss of immune tolerance post-infection, and reveal new possibilities for biomarker development in preclinical rheumatoid arthritis.
Authors
- S. Janna Bashar (ORCID: https://orcid.org/0000-0003-0779-1530)
- Ryan R. Adyniec
- Amin Titi
- Miriam A. Shelef (ORCID: https://orcid.org/0000-0002-8842-0303)
- Courtney B. Myhr
- Maxwell Parker
- Nat Murren
- Braedon T. Krisko
Institutions
- University of Wisconsin–Madison (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1553540
- Citations
- 3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- Congressionally Directed Medical Research Programs