Identification of mouse and human embryonic pancreatic cells with adult Procr+ progenitor transcriptomic and epigenomic characteristics
Our results show that, although the previously reported Procr<sup>+</sup> progenitor cell population could not be found in other adult pancreatic islet samples, a mesothelial cell population with a closely related transcriptional signature is present in both the mouse and human embryonic pancreas. Several lines of evidence presented in this work support a developmentally relevant function for these <i>Procr-like</i> mesothelial cells.
Authors
- Lucas dos Santos Bacigalupo
- Martín A. Rossotti (ORCID: https://orcid.org/0000-0002-8902-5532)
- Santiago A. Rodríguez‐Seguí (ORCID: https://orcid.org/0000-0003-2952-8485)
- Ana Carolina Heidenreich (ORCID: https://orcid.org/0000-0001-5102-019X)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
- Fundación Ciencias Exactas y Naturales (AR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fendo.2025.1543960
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Agencia Nacional de Promoción Científica y Tecnológica