Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes
These results highlight a critical period in disease progression, during which the microglia respond to <i>α</i>-synuclein, suggesting a transition in the role of microglia from the early to late stages of the disease.
Authors
- Brett A. McGregor (ORCID: https://orcid.org/0000-0003-3146-9699)
- Afrina Brishti (ORCID: https://orcid.org/0000-0003-1633-207X)
- Md. Obayed Raihan (ORCID: https://orcid.org/0000-0002-0095-5339)
- Junguk Hur (ORCID: https://orcid.org/0000-0002-0736-2149)
- James E. Porter
Institutions
- University of North Dakota (US)
- Chicago State University (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fnmol.2025.1544971
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Institutes of Health
- National Institute of General Medical Sciences