Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways
These results identified a critical role of entrectinib in promoting nerve cell damage by downregulating the expression of THBS1 while also inhibiting PI3K-AKT and TGF-β signaling pathways. Our findings will provide potential therapeutic targets for CNS-related toxicities.
Authors
- Qi Tang (ORCID: https://orcid.org/0000-0001-9614-1075)
- Ji‐Fu Wei (ORCID: https://orcid.org/0000-0001-6412-3251)
- Dan Zhao (ORCID: https://orcid.org/0000-0003-3834-0142)
- Jiahong Dong (ORCID: https://orcid.org/0000-0002-8067-4691)
- Jiayu Wen
- Yuhao Sun (ORCID: https://orcid.org/0000-0001-6640-6888)
- Zhixian Liu
- Qi Yang (ORCID: https://orcid.org/0009-0001-3329-5189)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fphar.2025.1489210
- Citations
- 3
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- China International Medical Foundation
- Jiangsu Cancer Hospital