Partial protective efficacy of the current licensed Japanese encephalitis live vaccine against the emerging genotype I Japanese encephalitis virus isolated from sheep

The results of this study suggest that while the SA14-14-2 (GIII) attenuated live vaccine offers partial protection against sheep-derived GI strains, it is not fully effective against heterologous strains like SH2201 (GI). This highlights a significant gap in the ability of the current vaccines to protect across different JEV genotypes and host species. In contrast, the SD12-F120 (GI) vaccine demonstrated stronger protection against the homologous SH2201 (GI) strain. These findings indicate a pressing need for the development of new vaccination strategies that can provide broader and more effective protection against JE, particularly in diverse host species and against a wide range of JEV genotypes.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-02-13
DOI
https://doi.org/10.3389/fimmu.2025.1513261
Citations
2
Primary Topic
Mosquito-borne diseases and control
Type
article
Field-Weighted Citation Impact
3.76

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article

Partial protective efficacy of the current licensed Japanese encephalitis live vaccine against the emerging genotype I Japanese encephalitis virus isolated from sheep

Juxiang Liu, Jiayang Zheng, Yafeng Qiu, Donghua Shao et al.
2 citations
Frontiers in Immunology
Mosquito-borne diseases and control
3.76
article

Partial protective efficacy of the current licensed Japanese encephalitis live vaccine against the emerging genotype I Japanese encephalitis virus isolated from sheep

Juxiang Liu, Jiayang Zheng, Yafeng Qiu, Donghua Shao, Jianchao Wei, Junjie Zhang, Ke Liu, Hailong Zhang, Dan Li, Beibei Li, Yan Zhang, Zongjie Li, Zhiyong Ma
article en
2 citations

Abstract

The results of this study suggest that while the SA14-14-2 (GIII) attenuated live vaccine offers partial protection against sheep-derived GI strains, it is not fully effective against heterologous strains like SH2201 (GI). This highlights a significant gap in the ability of the current vaccines to protect across different JEV genotypes and host species. In contrast, the SD12-F120 (GI) vaccine demonstrated stronger protection against the homologous SH2201 (GI) strain. These findings indicate a pressing need for the development of new vaccination strategies that can provide broader and more effective protection against JE, particularly in diverse host species and against a wide range of JEV genotypes.

Frontiers in ImmunologyVol. 16
Hebei Agricultural University (CN), Shanghai Veterinary Research Institute (CN), Chinese Academy of Agricultural Sciences (CN)
Natural Science Foundation of Shanghai, National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality, Chinese Academy of Agricultural Sciences, National Key Research and Development Program of China, Agricultural Science and Technology Innovation Program
Good health and well-being
Openalex Percentile: Top 9%
Mosquito-borne diseases and control
3.76
DOIOpen Access PDFOpenAlex
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