Single-cell and spatial analysis reveals the interaction between ITLN1+ foam cells and SPP1+ macrophages in atherosclerosis
Our findings underscore the critical crosstalk between ITLN1<sup>+</sup> foam cells and SPP1<sup>+</sup> macrophages in promoting lipid accumulation and AS progression. Targeting this cell-cell interaction may offer new therapeutic avenues for managing atherosclerosis. Further validation of these mechanisms is necessary to develop effective immunotherapeutic strategies against AS.
Authors
- Zongfu Pan (ORCID: https://orcid.org/0000-0002-4054-6660)
- Minghao Yin (ORCID: https://orcid.org/0000-0002-6226-2394)
- Yan‐Ping Che
- Ruidan Zhang (ORCID: https://orcid.org/0000-0002-4924-8766)
- Yingying Gong (ORCID: https://orcid.org/0000-0001-7965-2236)
- Shanshan Wang (ORCID: https://orcid.org/0000-0001-8249-4291)
- Kening Li
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University of Technology (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fcvm.2025.1510082
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.39