A single point mutation on FLT3L-Fc protein increases the risk of immunogenicity
This finding underscores the necessity for careful evaluation of mutations during the engineering of protein therapeutics. The integration of multiple immunogenicity risk assessment tools offers critical insights for informed decision-making in candidate sequence design and therapeutic lead selection.
Authors
- Yinyin Li (ORCID: https://orcid.org/0000-0001-6195-8309)
- Sivan Cohen (ORCID: https://orcid.org/0000-0001-6213-6200)
- Alavattam Sreedhara (ORCID: https://orcid.org/0000-0002-9227-2446)
- Patrick Wu (ORCID: https://orcid.org/0000-0002-1437-6688)
- Christine Moussion (ORCID: https://orcid.org/0000-0002-1641-4094)
- Joshua G. Gober (ORCID: https://orcid.org/0000-0002-2477-3329)
- Jérémie Decalf (ORCID: https://orcid.org/0000-0002-1113-6128)
- Travis W. Bainbridge (ORCID: https://orcid.org/0000-0002-7771-7574)
- Mercedesz Balázs (ORCID: https://orcid.org/0000-0001-5993-3049)
- Adel M. ElSohly (ORCID: https://orcid.org/0000-0003-4206-7548)
- Christopher C. Kemball (ORCID: https://orcid.org/0009-0003-9068-8338)
- Zicheng Hu (ORCID: https://orcid.org/0000-0002-4168-1725)
- Qui Phung (ORCID: https://orcid.org/0000-0001-6472-4567)
- Peter Tran (ORCID: https://orcid.org/0000-0002-2232-5979)
- Jonathan Zarzar
- Dongping He
- Zhengmao Ye (ORCID: https://orcid.org/0000-0002-1096-1919)
- Nicole Stephens (ORCID: https://orcid.org/0000-0002-6088-7526)
- Zhaojun Yin
- Zhenru Zhou
- Sien Tam
- Dan Qin
Institutions
- Genomic Health (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1519452
- Citations
- 3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 4.08