Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma

Our analysis identified four significant cross-disease mitochondrial markers: <i>EFHD1, SASH1, FAM110B,</i> and <i>SLC25A18</i>. These markers showed both shared and unique expression profiles in AD and GBM, suggesting a common mitochondrial mechanism contributing to both diseases. Additionally, oligodendrocytes and their interactions with astrocytes were implicated in disease progression, particularly through the APP signaling pathway. Key hub genes, such as <i>HS6ST3</i> and <i>TUBB2B</i>, were identified across different cellular subpopulations, highlighting a cell-specific co-expression network linked to mitochondrial function.