The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT
Our study unveils a novel mechanism involved in high glucose-induced cell hypertrophy, offering new insights into the understanding and treatment of early pathological mechanisms in diabetic nephropathy.
Authors
- Lianxiang Duan
- Yu Cao (ORCID: https://orcid.org/0000-0002-2009-4556)
- Yunqing Tang
- Lin Liao (ORCID: https://orcid.org/0000-0002-0278-4879)
- Qiming Xu (ORCID: https://orcid.org/0000-0001-7762-1794)
- Jianrao Lu (ORCID: https://orcid.org/0000-0002-3384-3296)
- Pengyu Tao (ORCID: https://orcid.org/0000-0001-5024-8686)
- Wenrui Liu (ORCID: https://orcid.org/0000-0002-9501-7053)
- Jie Chen (ORCID: https://orcid.org/0000-0002-6808-1076)
- Wenhao Chen (ORCID: https://orcid.org/0000-0002-0626-3739)
- Ziyang Liu (ORCID: https://orcid.org/0000-0003-1984-7378)
- Jing Hu (ORCID: https://orcid.org/0000-0002-6803-6240)
- Jie Xu (ORCID: https://orcid.org/0000-0001-7095-5580)
- Yue Guo (ORCID: https://orcid.org/0009-0001-6335-8654)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Seventh People's Hospital of Shanghai (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- Acta Diabetologica
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1007/s00592-025-02464-9
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China