High-temporal-resolution dynamic PET imaging based on a kinetic-induced voxel filter

<i>Objective</i>. Dynamic positron emission tomography (dPET) is an important molecular imaging technology that is used for the clinical diagnosis, staging, and treatment of various human cancers. Higher temporal imaging resolutions are desired for the early stages of radioactive tracer metabolism. However, images reconstructed from raw data with shorter frame durations have lower image signal-to-noise ratios (SNRs) and unexpected spatial resolutions.<i>Approach</i>. To address these issues, this paper proposes a kinetic-induced voxel filtering technique for processing noisy and distorted dPET images. This method extracts the inherent motion information contained in the target PET image and effectively uses this information to construct an image filter for each PET image frame. To ensure that the filtered image remains undistorted, we integrate and reorganize the information from each frame along the temporal dimension. In addition, our method applies repeated filtering operations to the image to produce optimal denoising results.<i>Main results</i>. The effectiveness of the proposed method is validated on both simulated and clinical dPET data, with quantitative evaluations of dynamic images and pharmacokinetic parameter maps calculated via the peak SNR and mean structural similarity index measure. Compared with the state-of-the-art methods, our method achieves superior results in both qualitative and quantitative imaging scenarios.<i>Significance</i>. It exhibits commendable performance and high interpretability and is demonstrated to be both effective and feasible in high-temporal-resolution dynamic PET imaging tasks.