PDK2-enhanced glycolysis aggravates fibrosis via IL11 signaling pathway in Graves’ orbitopathy
PDK2-enhanced glycolysis exacerbates fibrosis via IL11-IL11Rα signaling pathway, shedding light on a potential therapeutic role of metabolic modulators such as DCA in GO treatment.
Authors
- Kang Xue (ORCID: https://orcid.org/0000-0003-4621-0217)
- Yinan Han (ORCID: https://orcid.org/0000-0002-5974-3525)
- Jiang Qian (ORCID: https://orcid.org/0000-0002-4287-3497)
- Zhiyu Peng
- Jinghan Wang (ORCID: https://orcid.org/0000-0002-8932-0267)
- Jihong Wu (ORCID: https://orcid.org/0000-0003-3892-5757)
- Xiaofeng Li (ORCID: https://orcid.org/0009-0005-3765-0124)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-7888-8204)
- Lu Gan (ORCID: https://orcid.org/0000-0003-1056-7660)
- Ruiqi Ma (ORCID: https://orcid.org/0000-0003-4340-2862)
- Jie Guo (ORCID: https://orcid.org/0000-0003-1765-3131)
- Jie Ding
- Rui Huang (ORCID: https://orcid.org/0000-0002-4103-8537)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1537365
- Citations
- 1
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China