Transcriptomic analysis of the effects exerted by curcumin on dihydrotestosterone-induced ovarian granulosa cells
High androgen levels may disrupt steroid hormone synthesis and lipid metabolism pathways associated with granulosa cell development, thereby activating AR and inhibiting estrogen biosynthesis. Curcumin restores granulosa cell development by correcting abnormal steroid gene expression and disordered lipid fatty acid metabolism.
Authors
- Dejian Chen (ORCID: https://orcid.org/0000-0001-6576-3939)
- Yaling Zhang (ORCID: https://orcid.org/0000-0003-1174-6599)
- Qian Yu (ORCID: https://orcid.org/0000-0003-1953-1170)
- Jisuo Zheng
- Shuhao Sheng
- Lingshi Cai
Institutions
- Jiaxing University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fendo.2025.1522269
- Citations
- 2
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 3.63