Synergistic Warriors: Design and Synthesis of Dual-Acting Schiff-Based Threaded 1,2,3-Triazole Hybrids for Potent Antineoplastic and Anti-Mycobacterial Activities
Structure-activity relationship (SAR) analysis identified three pivotal pharmacophores; 1,2,3-triazole, aromatic ring system (substituted with halogens and -NO2), and imine functionalities as crucial for the development of dual inhibitors targeting cancer and tuberculosis, showcasing an outstanding in silico ADMET profile. Therefore, these compounds merit consideration as noteworthy pharmacological lead molecules in the realm of cancer and tuberculosis drug discovery and development.
Authors
- Santosh Karajgi (ORCID: https://orcid.org/0000-0001-7804-3033)
- R.S. Kulkarni
- Mohana Vamsi Nuli (ORCID: https://orcid.org/0000-0003-1900-6317)
- Ravindra Kulkarni
- Vinayak Walhekar
- D. V. R. N. Bhikshapathi (ORCID: https://orcid.org/0000-0002-5521-2137)
- Anil Kumar Garige
- R. M. Pawar (ORCID: https://orcid.org/0009-0004-2530-3574)
- Ashwini Patil
- Dharmesh Deore
Institutions
- Sambalpur University (IN)
- Dr. Reddy's Laboratories (United States) (US)
- B. J. Medical College & Sassoon Hospital (IN)
- Dr. Reddy's Laboratories (India) (IN)
- Kaloji Narayana Rao University of Health Sciences (IN)
- Hindu College of Pharmacy (IN)
- Jawaharlal Nehru Technological University Anantapur (IN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-02-13
- DOI
- https://doi.org/10.2174/0115734064318062250206104355
- Citations
- 1
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 0.81