Design, Synthesis, Characterization, and Antitumor Activities of Benzimidazole-functionalized Organoruthenium Complexes Bearing Fluorine Group
Furthermore, apoptosis assessed by double labeling with Annexin V-FITC/PI indicated that complexes 1b and 1d can effectively induce apoptosis and inhibit cell proliferation at the S phase in <i>SH-SY5Y</i> cells. Taken together, Ru(II)NHC complexes containing the 4- fluorobenzyl group have significant potential for the development of novel, highly effective anticancer agents.
Authors
- Yetkın Gök (ORCID: https://orcid.org/0000-0003-3993-7733)
- Ramazan Paşahan (ORCID: https://orcid.org/0000-0002-3221-1422)
- Aydın Aktaş (ORCID: https://orcid.org/0000-0001-8496-6782)
- Irmak İçen Taşkın (ORCID: https://orcid.org/0000-0002-1612-0563)
- Özlem Demirci (ORCID: https://orcid.org/0000-0003-0690-5807)
- Aziz Paşahan (ORCID: https://orcid.org/0000-0002-0657-3884)
- Meryem Rüveyda Sever
Institutions
- Inonu University (TR)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-02-13
- DOI
- https://doi.org/10.2174/0115734064331622241113032042
- Citations
- 1
- Primary Topic
- Synthesis of Tetrazole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.94