Distinct gene signatures define the epithelial cell features of mucinous appendiceal neoplasms and pseudomyxoma metastases
Our study defined tumor cell gene signatures of AMN and PMP, successfully overcoming challenges of low cellularity and mucinous composition of these tumors. These gene expression signatures provide insights on tumor origin and differentiation, together with the identification of novel treatment targets. The heterogeneity observed within an individual tumor and between different tumors from the same patient, represents a potential source of treatment resistance.
Authors
- Xiangqi Bai (ORCID: https://orcid.org/0000-0003-4524-8862)
- Anuja Sathe (ORCID: https://orcid.org/0000-0002-2100-0013)
- Byrne Lee (ORCID: https://orcid.org/0000-0002-1950-0262)
- Hanlee P. Ji
- Carlos Ayala
- Susan M. Grimes (ORCID: https://orcid.org/0000-0003-1144-4128)
- Jeanne Shen (ORCID: https://orcid.org/0000-0002-4745-7644)
- George A. Poultsides (ORCID: https://orcid.org/0000-0002-7584-0405)
Institutions
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fgene.2025.1536982
- Citations
- 3
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- National Institutes of Health