Engineered Anti-Microbial Peptides Inhibit Cell Viability, Promote Apoptosis, and Induce Cell Cycle Arrest in SW620 Human Colon Adenocarcinoma Cells
Our findings revealed that EAMPs exhibited significant anti-cancer activity against CRC cells <i>in vitro</i> while sparing normal epithelial cells. These results suggest that EAMPs may offer a potential therapeutic approach for colorectal cancer and warrant further investigation.
Authors
- Sheema Hashem (ORCID: https://orcid.org/0000-0003-2986-3718)
- Muhammad Suleman (ORCID: https://orcid.org/0000-0003-2914-1862)
- Shahab Uddin (ORCID: https://orcid.org/0000-0003-1886-6710)
- Sabah Nisar (ORCID: https://orcid.org/0000-0003-2606-7097)
- Sérgio Crovella (ORCID: https://orcid.org/0000-0001-8493-1168)
- Carlos André dos Santos-Silva (ORCID: https://orcid.org/0000-0003-0020-9763)
- Lama Soubra (ORCID: https://orcid.org/0000-0002-1129-4513)
- Ana Maria Benko‐Iseppon (ORCID: https://orcid.org/0000-0002-0575-3197)
- Marx Oliveira de Lima
- Jericha Miles Pamiloza Mateo
- Maysaloun Merhi (ORCID: https://orcid.org/0000-0002-8016-3699)
- Mohammad Haris (ORCID: https://orcid.org/0000-0002-4945-2935)
- Lívia Maria Batista Vilela
- Juliana Silva (ORCID: https://orcid.org/0000-0002-5546-932X)
- Ajaz Ahmad Bhat (ORCID: https://orcid.org/0000-0003-3640-6275)
- Haissam Abou Saleh
- Kirti S. Prabhu
Institutions
- Universidade Federal de Pernambuco (BR)
- National Center for Cancer Care and Research (QA)
- Hamad Medical Corporation (QA)
- Qatar University (QA)
- University of Pennsylvania (US)
Publication Details
- Journal
- Current Protein and Peptide Science
- Published
- 2025-02-13
- DOI
- https://doi.org/10.2174/0113892037363898250110053529
- Citations
- 1
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 1.16