Palladium-Catalyzed Heck Cyclization/Reductive Aminocarbonylation of Carbamoyl Chlorides with Nitroarenes
A palladium-catalyzed Heck cyclization/reductive aminocarbonylation was developed for alkene-tethered carbamoyl chlorides with nitroarenes using Mo(CO)6 as a convenient CO surrogate and reductant. This process constructed one C–N bond and two C–C bonds, yielding a variety of amidated oxindoles/γ-lactams with an all-carbon quaternary stereocenter under gas-free conditions. The transformation exhibited a wide range of substrate compatibility and exceptional functional group tolerance.
Authors
- Jun‐Min Liu (ORCID: https://orcid.org/0000-0002-9876-0715)
- Jun‐Fang Gong (ORCID: https://orcid.org/0000-0002-5299-1323)
- Chunjie Ni (ORCID: https://orcid.org/0000-0003-1479-5484)
- Bolin Zhu (ORCID: https://orcid.org/0000-0002-6846-566X)
- Zhe Zhou
- Chen Chen (ORCID: https://orcid.org/0000-0002-5388-9611)
- Ziyi Wang (ORCID: https://orcid.org/0009-0005-3334-3266)
- Xin D. Gao (ORCID: https://orcid.org/0000-0002-7108-3574)
- Ziliang Cui (ORCID: https://orcid.org/0009-0004-9178-5313)
Institutions
- Tianjin Normal University (CN)
- Yancheng Teachers University (CN)
Publication Details
- Journal
- Letters in Organic Chemistry
- Published
- 2025-02-13
- DOI
- https://doi.org/10.2174/0115701786367852250207102915
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00