Modulation of double-negative T cells by Huang-Lian-Jie-Du Decoction attenuates neuroinflammation in ischemic stroke: insights from single-cell transcriptomics
These results suggest that HLJD exerts neuroprotective effects in IS by modulating the activity and distribution of DNT cells, offering valuable insights into the therapeutic potential of traditional Chinese medicine for the treatment of IS. Further studies are required to elucidate the mechanisms underlying DNT-mediated immune responses in IS and to explore the broader applications of HLJD in other neuroinflammatory conditions.
Authors
- Yuanhua Li (ORCID: https://orcid.org/0000-0001-8455-995X)
- Haojia Zhang
- Ming Jiang (ORCID: https://orcid.org/0000-0001-9748-7633)
- Yan Daniel Zhao (ORCID: https://orcid.org/0000-0003-3448-0527)
- Wei Wang
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-5344-2625)
- Qingguo Wang (ORCID: https://orcid.org/0000-0003-2752-1925)
- Zijin Sun
- Zhaoyi Wang (ORCID: https://orcid.org/0000-0002-1585-9649)
- Fafeng Cheng (ORCID: https://orcid.org/0000-0002-3409-1196)
- Tieshan Wang
- Qi Shao
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1537277
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53