Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus
Taken together, our findings highlight the altered immunological landscape of SLE follicles, likely fueled by potent inflammatory signals such as sustained type I IFN and/or IL-21 signaling. Our work provides novel insights into the spatial molecular and cellular signatures of SLE follicular B and T<sub>FH</sub> cell dynamics, and points to druggable targets to restore immune tolerance and enhance vaccine responses in SLE patients.
Authors
- Yannick D. Müller (ORCID: https://orcid.org/0000-0003-0513-7156)
- Raphaël Gottardo (ORCID: https://orcid.org/0000-0002-3867-0232)
- Bernat Bramon Mora (ORCID: https://orcid.org/0000-0003-4735-567X)
- Denis Comte (ORCID: https://orcid.org/0000-0002-6605-1498)
- Perla M. Del Río Estrada (ORCID: https://orcid.org/0000-0003-3366-3268)
- Spiros Georgakis (ORCID: https://orcid.org/0000-0002-9398-3143)
- Ashish Sharma (ORCID: https://orcid.org/0000-0001-9444-7046)
- Kalliopi Ioannidou (ORCID: https://orcid.org/0000-0001-9097-4199)
- Laurence de Leval (ORCID: https://orcid.org/0000-0003-3994-516X)
- Constantinos Petrovas (ORCID: https://orcid.org/0000-0002-5067-5810)
- Michail Orfanakis
- Giuseppe Pantaleo (ORCID: https://orcid.org/0000-0001-6161-8590)
- Cloé Brenna
Institutions
- SIB Swiss Institute of Bioinformatics (CH)
- Emory University (US)
- Instituto Nacional de Enfermedades Respiratorias (MX)
- University of Lausanne (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1530327
- Citations
- 2
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Centre Hospitalier Universitaire Vaudois