Distinct response to IL-1β blockade in liver- and lung-specific metastasis mouse models of pancreatic cancer with heterogeneous tumor microenvironments
This study reveals the differential responses of organ-specific metastasis mouse models of PDAC with distinct TMEs to anti-IL-1β and anti-PD-1 treatments, suggesting that treatment response is context-dependent and affected by TME heterogeneity.
Authors
- Heng‐Chung Kung (ORCID: https://orcid.org/0000-0002-9330-0971)
- Juan Fu
- Haley Zlomke (ORCID: https://orcid.org/0000-0002-3544-6841)
- Michael Loycano
- Birginia Espinoza (ORCID: https://orcid.org/0000-0002-0227-1176)
- Sophia Y. Chen
- India Washington
- Lei Zheng (ORCID: https://orcid.org/0000-0003-4163-2541)
- Kai Chen (ORCID: https://orcid.org/0000-0002-8647-1182)
- Rulin Wang (ORCID: https://orcid.org/0000-0002-6177-1058)
- William R. Burns (ORCID: https://orcid.org/0000-0002-3049-4377)
- Kaiyi Mu
Institutions
- Johns Hopkins University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1186/s40164-025-00607-w
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Bristol-Myers Squibb
- National Institutes of Health
- Sidney Kimmel Comprehensive Cancer Center
- National Cancer Institute