CAR-macrophages targets CD26 to eliminate chronic myeloid leukemia stem cells
This study demonstrates that CD26 CAR-M effectively targets and phagocytizes CD26-positive CML cells, implying that targeting CD26 with CAR-M could be a viable method for eradicating CML-LSCs. Furthermore, our discoveries illuminate the potential application of CAR-M in treating hematological malignancies.
Authors
- Huang Zhenglan
- Hongyan Zhou (ORCID: https://orcid.org/0000-0002-9878-2519)
- Zuowei Yuan
- Ying Yuan
- Wenli Feng (ORCID: https://orcid.org/0000-0003-0889-8348)
- Jiang Guoyun
- Qin Yuefeng
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1186/s40164-025-00608-9
- Citations
- 6
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China