Mitochondrial Dysfunction in Osteosarcoma Patients

This review aims to explore the relationship between mitochondrial dysfunction and osteosarcoma progression. Osteosarcoma, a highly malignant primary bone tumor, has long been linked to various metabolic alterations, including mitochondrial anomalies. Mitochondria, known for their roles in energy production, reactive oxygen species regulation, and apoptosis, are implicated in cancer pathogenesis. This paper consolidates evidence from multiple studies, highlighting how mitochondrial dysfunction contributes to osteosarcoma development, tumor growth, and metastasis. Findings suggest that abnormal mitochondrial functions—ranging from disrupted energy metabolism to metabolic reprogramming—significantly impact tumor progression. Despite these insights, challenges persist in establishing a direct causal relationship. The review identifies potential therapeutic strategies targeting mitochondrial pathways and emphasizes the need for further studies to clarify mechanisms linking mitochondrial dysfunction and osteosarcoma