Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma
The critical role of the HIF1A-LDHA axis in ESCC highlights its potential as a therapeutic target, underscoring the need for future clinical trials to validate the efficacy of HIF1A inhibitors in enhancing treatment outcomes.
Authors
- Dawei Bao
- Wubi Zhou (ORCID: https://orcid.org/0000-0001-8421-8768)
- Jian Huang (ORCID: https://orcid.org/0000-0002-0862-1384)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-9341-5832)
- Haiyan Liu (ORCID: https://orcid.org/0000-0002-0575-5416)
- Xia Chen (ORCID: https://orcid.org/0009-0009-6969-2969)
Institutions
- Xuzhou Medical College (CN)
- Huaian First People’s Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.4251/wjgo.v17.i3.103450
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81