Novel Directly Reprogrammed Smooth Muscle Cells Promote Vascular Regeneration as Microvascular Mural Cells
A combination of myocardin and all-<i>trans</i> retinoic acid in defined culture conditions efficiently reprogrammed human fibroblasts into contractile and functional SMCs. The rSMCs were shown to be effective for vascular repair and contributed to neovascularization through mural cells and various paracrine effects. These human rSMCs could represent a novel source for cell-based therapy and research.
Authors
- Young‐Jae Nam (ORCID: https://orcid.org/0000-0003-3063-2036)
- Young‐sup Yoon (ORCID: https://orcid.org/0000-0003-0051-0935)
- Cholomi Jung (ORCID: https://orcid.org/0000-0001-9067-3724)
- Shin‐Jeong Lee (ORCID: https://orcid.org/0000-0002-0780-0559)
- Nadia M. Chu (ORCID: https://orcid.org/0000-0003-1441-3589)
- Jee Eun Oh (ORCID: https://orcid.org/0000-0002-3469-8545)
- Chi V. Dang (ORCID: https://orcid.org/0000-0002-4031-2522)
- Seongho Bae (ORCID: https://orcid.org/0000-0002-3624-6649)
- Sangsung Kim (ORCID: https://orcid.org/0000-0001-9192-2614)
- Sangho Lee (ORCID: https://orcid.org/0000-0003-3771-7761)
- Jae‐Hyun Kim (ORCID: https://orcid.org/0000-0002-7403-7135)
- Eun Jig Lee (ORCID: https://orcid.org/0000-0002-9876-8370)
- Kyung‐Hee Kim (ORCID: https://orcid.org/0000-0003-0214-0296)
- Ji Woong Han
Institutions
- Emory University (US)
- Yonsei University (KR)
- Vanderbilt University (US)
- Severance Hospital (KR)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1161/circulationaha.124.070217
- Citations
- 2
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61