Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression
Aging impairs macrophage function through reduced efferocytosis and autophagy activation, limiting atherosclerosis regression. These results highlight the need to better define the mechanisms linking aging to atherosclerosis to develop targeted therapies for the aging population.
Authors
- Jonathan Salazar‐León (ORCID: https://orcid.org/0000-0002-0496-3782)
- Sabrina Robichaud (ORCID: https://orcid.org/0000-0001-5766-1094)
- Sasha A. Singh (ORCID: https://orcid.org/0000-0003-0929-3164)
- Adil Rasheed (ORCID: https://orcid.org/0000-0002-3204-6674)
- Leah I. Susser
- Dawn M. E. Bowdish (ORCID: https://orcid.org/0000-0001-6823-2957)
- Katey J. Rayner (ORCID: https://orcid.org/0000-0001-6230-426X)
- Elena Aïkawa (ORCID: https://orcid.org/0000-0001-7835-2135)
- Masanori Aikawa (ORCID: https://orcid.org/0000-0002-9275-2079)
- Michèle Geoffrion
- Victoria Lorant
- E.M.G.J. de Jong (ORCID: https://orcid.org/0000-0003-3872-5704)
- Christina Emerton
- Mireille I. Ouimet (ORCID: https://orcid.org/0000-0002-6831-5047)
- Isam Suliman
- Dominique Boucher (ORCID: https://orcid.org/0000-0003-2223-0117)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Ottawa (CA)
- McMaster University Medical Centre (CA)
- Institute for Respiratory Health (AU)
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1161/atvbaha.124.321662
- Citations
- 12
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 9.57