Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis <i>via</i> PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism
This study demonstrates that CGA inhibits HCC cell proliferation, migration, and invasion by inducing ferroptosis through the PTGS2/AKR1C3/GPX4 axis, suggesting its potential as a novel ferroptosis inducer or anti-HCC drug.
Authors
- Puhua Zeng (ORCID: https://orcid.org/0000-0001-6542-673X)
- Jingting Zhang (ORCID: https://orcid.org/0000-0001-5041-3629)
- K. Li
- Wenhui Gao (ORCID: https://orcid.org/0000-0001-6388-7452)
- Zhibin Wang (ORCID: https://orcid.org/0000-0001-8530-8837)
- Ling Wu
- Wei Peng (ORCID: https://orcid.org/0000-0001-8561-1430)
- Hongyao Chen (ORCID: https://orcid.org/0009-0009-4396-5869)
- Renyi Yang (ORCID: https://orcid.org/0000-0003-4839-6895)
- Peisen Xue
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Integrated Chinese Medicine (China) (HK)
- Hunan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.4251/wjgo.v17.i3.98844
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07